Protein Details: Gamma-aminobutyric acid receptor-associated protein-like 3

Protein ID

ICDB_Pro_1459

Protein Name

Gamma-aminobutyric acid receptor-associated protein-like 3

Gene Name

GABARAPL3

Organism

Homo sapiens (Human)

Length

117 amino acids

AlphaFoldDB

AF-Q9BY60-F1-model_v4.pdb

Function

Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane; the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Sequence

MKFQYKEVHPFEYRKKEGEKIRKKYPDRVPLIVEKAPKARVPDLDRRKYLVPSDLTDGQFYLLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDSHEEDDFLYVAYSNESVYGK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Ubiquitous. Expressed at very high levels in the brain; heart; peripheral blood leukocytes; liver; kidney; placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. Expressed at very low levels in thymus and small intestine. Expressed at very low levels in thymus and small intestine.

DOI ID

10.1006/geno.2001.6555